This 15th episode of The Pain Beat is the third and final of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, part one of this series here, and part two of this series here). In this episode, The Pain Beat spoke with a group of collaborators and former mentees to discuss what the discoveries mean for the somatosensory field, as well as stories and insights about what it was like working with Drs. Julius and Patapoutian during that time.
Episode 14: Nobel Prize- A Conversation with Ardem Patapoutian and Bertrand Coste
This is the second of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine that was awarded to David Julius and Ardem Patapoutian for their work on molecules important for somatosensation.
In this episode, The Pain Beat spoke with Ardem Patapoutian and Bertrand Coste to discuss their discovery of mechanically sensitive ion channels – Piezo1 and Piezo2.
Ardem Patapoutian, PhD, Scripps Research, California, USA Bertrand Coste, PhD, Aix-Marseille University, France and Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)
Episode 13: Nobel Prize- A Conversation with David Julius and Michael Caterina
This 13th episode of The Pain Beat is the first of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation.
In this episode, The Pain Beat spoke with Nobel Prize laureate David Julius and Michael Caterina, Johns Hopkins University School of Medicine, Maryland, USA, to discuss their discovery of TRPV1. The conversation provides insight regarding their thought processes and problem solving, the enduring challenges of scientific discoveries, and the fun they had along the way. Podcast participants include:
David Julius, PhD, University of California, San Francisco, USA Michael Caterina, MD, PhD, Johns Hopkins School of Medicine, Maryland, USA Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)
Episode 12: A Tribute to Stephen McMahon
The twelfth episode of The Pain Beat is dedicated to Stephen McMahon, PhD, FMedSci (1954-2021). Stephen, affectionately known as “Mac,” was a world class pain researcher, lecturer, and inspiration to many. Our podcast guests pay homage to “Mac” with stories that illustrate his influence on the pain research field, and those in it. He will be remembered not only for his seminal contributions to our understanding of pain, but also for his generous and enthusiastic personal spirit which has left an indelible mark.
Podcast participants include:
David Bennett, MB, PhD, University of Oxford, UK Gary Lewin, PhD, Max-Delbrück Center for Molecular Medicine, Berlin, Germany Irene Tracey, DPhil, University of Oxford, UK Franziska Denk, DPhil, King’s College London, UK (Host).
Episode 11: The Evolution of Nociceptors
For its eleventh episode, The Pain Beat brought together experts to discuss the biological evolution of nociceptors, their subtypes, and plasticity as part of the Gulf Coast Consortium’s #Pain2021 Webinar Series. These experts study nociceptors across a variety of animal models, including Drosophila, C. elegans, cephalopods, rodents, and humans. The discussion focused on how an evolutionary perspective brings novel insights into the role and function of nociceptors and if, why, and how organisms experience pain. Podcast participants include:
Greg Neely, PhD, University of Sydney, Australia Edgar T. Walters, PhD, University of Texas Health Science Center at Houston, USA Robyn Crook, PhD, San Francisco State University, California, USA Ewan St. John Smith, PhD, University of Cambridge, UK Ted Price, PhD, University of Texas at Dallas, USA (Moderator) Peter Grace, PhD, University of Texas MD Anderson Cancer Center, USA (Host)
Ep: 10 What has it been like to move research forward during the pandemic?
For its tenth episode, The Pain Beat brought together guests from a variety of career stages to share their experiences conducting pain and pain-related research during the COVID-19 pandemic. Their discussion highlighted unique and shared experiences, how research priorities and strategies shifted in response to the pandemic, as well as ways in which colleagues found and offered support.
Podcast participants include:
Theanne Griffith, PhD, University of California, Davis, US
Kelly Smith, PhD, University of Pittsburgh, US
Kara Marshall, PhD, Baylor University, Texas, US
Lindsay Ejoh, PhD Candidate, University of Pennsylvania, US
Tayler Sheahan, PhD, University of Pittsburgh, US (Moderator)
Episode 9: How is Pain Measured if it is Subjective?
Dec 7, 2021
For its ninth episode, the Pain Beat brought together experts in how pain is measured clinically and experimentally. This multidisciplinary group discussed what is the difference between pain and nociception, why organisms experience pain, and whether pain can be objectively measured since it is a subjective experience. Additionally, the group explored why researchers have relied on the measurement of nociception for so long and offer paths forward for the research community including a discussion of new technologies. This episode is joined by Ishmail Abdus-Saboor, Carl Saab, Vivianne Tawfik, Mark Zylka, and Tayler Sheahan.
Episode 8: Studying and Understanding Sex Differences in Pain: the How and the Why
December 7, 2021
For its eighth episode, The Pain Beat gathered together a group of pain researchers with expertise in the study of sex differences in pain. The group discussed their own discoveries of sex differences in pain in the course of their research, why pain investigators should pay attention to sex differences and how they should go about examining them, and much more. Featuring Gregory Dussor, Jeffery Mogil, Anne Murphy, and Kate Sadler.
Episode 7: Brain Imaging of Pain in People: What Have We Learned? Where Are We Going?
May 26, 2021
Christian Büchel, MD, Irene Tracy DPhil, Tor Wager, Ph.D., and Howard Fields, MD/Ph.D. join the Pain Beat for a lively discussion on all things neuroimaging. This episode focuses on how studies of expectation and the placebo effect have advanced our understanding of this area. What have we learned so far? Can imaging the pain brain be a diagnostic tool? Where will neuroimaging take us in the future?
Episode 6: Communicating Science in an Empathic and Inclusive Way: Why - and How - Should Pain Researchers Do It?
February 21, 2021
There are some major challenges chronic pain research faces in different parts of the world… what are they and how can we address them? How can we enhance the general public’s interest in chronic pain research? How can professional science communicators create narratives that are able to transform the way we as a society talk about chronic pain?
Episode 5: Debate: Coding of Sensory Modalities- Labeled Lines or Population Coding?
January 8, 2021
In this episode, Diana Bautista, Mark Hoon, Nick Betley, and Adam Hantman debate how somatosensory modalities are encoded by the nervous system. Are there labeled lines or is it by population coding? Does it depend on where in the nervous system- brain, spinal cord, or periphery?
Episode 4: How Human Tissue and IPS Cells Are Transforming Pain Research.
October 26, 2020
For the fourth episode, The Pain Beat gathered together Alex Chamessian, Mike Hildebrand, Steve Davidson, Laura stone and Clifford Woolf via Zoom to discuss the use of human tissue in pain research and prospects for clinical translation of new knowledge emerging from this approach. Podcast participants include:
Episode 3: The Transition from Acute to Chronic Pain
Ted Price moderates other leading pain researchers Vania Apkarian, Annemieke Kavelaars, Anne Louise Oaklander and Arkady Khoutorsky in a lively discussion about the molecules and circuits that contribute to the transition from acute to chronic pain. What is this critical transition and when does it happen? What does it mean for designing therapeutics and treating pain?
Episode 2: Optogenetics and Chemogenetics for Pain Treatment: How Feasible Are They? How Effective Could They Be?
In the second episode of The Pain Beat, Stephani Sutherland moderates a discussion between Allan Basbaum, Rob Gereau and Yarimar Carrasquillo about whether optogenetics and chemogenetics are feasible approaches to pain treatment, and if so, how effective they might be.
Episode 1: Pain Targets: Molecules? Cells? Circuits? Systems?
The premier episode of the Pain Beat podcast. Ardem Patapoutian, Cheryl Stucky, Sarah Ross and Alex Chesler have a wide ranging discussion that addresses issues related to the question: What Biological Levels Should Be Targeted to Produce the Most Effective Pain Therapies: Molecules? Cells? Circuits? Or Systems? Stephani Sutherland moderates this gang of leading pain researchers. Hosted by the IASP Pain Research Forum (https://www.painresearchforum.org). And also found on Spotify and iTunes.