Publications
2022
A Comparison of the Cellular and Molecular Atlases of the Macaque and Mouse Dorsal Horns.Arokiaraj, C. M., Kleyman, M., Chamessian, A., Shiers, S., Kang, B., Kennedy, M. M., ... & Seal, R. P. (2022) bioRxiv
Intraspinal Injection of the AAV Encoded Chemogenetic Receptor PSAM-GlyR to Determine the Functional Roles of Spinal Dorsal Horn Neurons. Arokiaraj CM, Noh MC, and Seal RP In Contemporary Approaches to the Study of Pain: from Molecules to Neural Networks. Neuromethods (Springer Nature) Editor RP Seal.
Multiprobe Fluorescent In Situ Hybridization in the Rodent and Human Somatosensory System. Ferreira DW, Arokiaraj CM and Seal RP (2022). In Contemporary Approaches to the Study of Pain: from Molecules to Neural Networks. Neuromethods (Springer Nature) Editor RP Seal.
2021
Outer hair cell glutamate signaling through type II spiral ganglion afferents activates neurons in the cochlear nucleus in response to non-damaging sounds. Catherine J.C. Weisz*, Sean-Paul G. Williams, Chad S. Eckard, Christopher B. Divito, David W. Ferreira, Kristen N. Fantetti, Shenin A. Dettwyler, Hou-Ming Cai, Maria E. Rubio†, Karl Kandler and Rebecca P. Seal*† J. Neurosci epub 2021
Human cells and networks of pain: Transforming pain target identification and therapeutic development Renthal W, Chamessian A, Curatolo M, Davidson S, Burton M, Dib-Hajj S, Dougherty PM, Ebert AD, Gereau RW 4th, Ghetti A, Gold MS, Hoben G, Menichella DM, Mercier P, Ray WZ, Salvemini D, Seal RP, Waxman S, Woolf CJ, Stucky CL, Price TJ Neuron epub 2021
2020
Mechanical allodynia circuitry in the dorsal horn is defined by the nature of the injury. Peirs, C, Williams, SPG, Zhao, X, Arokiaraj, CM, Ferreira, D, Noh, M, Smith, KM, Halder, P, Corrigan, K, Gideon, J, Lee, SJ, Gatto, G, Chi, D, Ross, SE, Goulding, M, Seal, RP. Neuron epub 2020 Nov 11. Download here.
A functional topographic map for spinal sensorimotor reflexes. Gatto, G, Bourane, S, Ren, X, Fenton, P, Halder, P, Seal, RP, Goulding M. Neuron epub 2020 Nov 11
Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission
Cunha C, Smiley JF, Chuhma N, Shah R, Bleiwas C, Menezes EC, Seal RP, Edwards RH, Rayport S, Ansorge MS, Castellanos FX, Teixeira CM. Mol Psychiatry. 2020 May 12. doi: 10.1038/s41380-020-0763-z. Online ahead of print.
PMID: 32398719
2018
Uncovering the Cells and Circuits of Touch in Normal and Pathological Settings
Moehring, F. Halder P, Seal RP, Stucky CL
Neuron (2018) 100(2) 349-360.
A Critical Role for Dopamine D5 Receptors in Pain Chronicity in Male Mice.
Megat, S., S. Shiers, JK Moy, P. Barragan-Iglesias, G. Pradhan, Seal RP, G. Dussor and TJ Price
J. Neurosci. (2018) 38(2): 379-397.
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2017
Layer- and Cell type-Selective Co-transmission by a Basal Forebrain Cholinergic Projection to the Olfactory Bulb.
Case DT, Burton SD, Gedeon JY, Williams S-PG, Urban NN, Seal RP.
Nat Comm (2017) 8:652.
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2016
Neural Pain Circuits: recent advances and current views.
Peirs C, Seal RP.
Science (2016) 354(6312):578-584. Review.
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Illuminating the Gap: Neuronal Cross-Talk within Sensory Ganglia and Persistent Pain.
Seal RP.
Neuron (2016) 91: 950-951
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Do the Distinct Synaptic Properties of VGLUTs Shape Pain?
Seal RP.
Neurochem Int.(2016) 98:82-88. Review
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Ensuring Transparency and Minimization of Methodologic Bias in Preclinical Pain Research: PPRECISE Considerations. Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G.
Pain (2016) 157(4):901-9.
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Cell Biology of Tactile Afferents
Seal RP and Lumpkin EA.
Affective Touch and the Neurophysiology of CT Afferents, 49-59. (Eds. Hakan Olausson, Johan Wessberg, India Morrison, Frances McGlong) Springer Press.
2015
Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson’s Disease.
Divito CB, Steece-Collier K, Case DT, Williams SP, Stancati JA, Zhi L, Rubio ME, Sortwell CE, Collier TJ, Sulzer D, Edwards RH, Zhang H, Seal RP.
J Neurosci. (2015) 35(45):14983-99.
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Targeting Toll-like receptors to treat chronic pain.
Peirs C, Seal RP.
Nat Med. (2015) 21(11):1251-2.
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Dorsal Horn Circuits for Persistent Mechanical Pain.
Peirs C, Williams SPG, Zhao X, Walsh CE, Gedeon JY, Cagle NE, Goldring AC, Hioki H, Liu Z, Marell PS, Seal RP.
Neuron. 87(4):797-812.
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VGLUT3-independent Communication from Cochlea to Brain Detects Tissue-damaging Noise.
Flores EN, Madathany T, Hogan AK, Kumar G, Seal RP, Edwards RH, Liberman MC, and Garcia-Anoveros J.
Curr. Biol. 25(5): 606-612.
Presynaptic Inhibition of Optogenetically Identified VGluT3+ Sensory Fibres by Opioids and Baclofen.
Honsek S, Seal RP, and Sandkühler J.
Pain 156(2): 243-251.
2014
A Glutamatergic Reward Input from the Dorsal Raphe to Ventral Tegmental Area Dopamine Neurons.
Qi J, Zhang S, Wang HL, Wang H, Aceves Buendia J, Hoffman A, Lupica C, Seal RP, and Morales M.
Nat. Comm. 5 (5390).
An Unconventional Glutamatergic Circuit in the Retina Formed by vGluT3 Amacrine Cells.
Lee S*, Chen L*, Chen M*, Ye M, Seal RP, and Zhou ZJ.
Neuron 84(4): 1-8.
A Novel Population of Glomerular Neurons Controls Sensory Information Transfer in the Mouse Olfactory Bulb.Tatti R*, Bhaukaurally K*, Gschwend O*, Seal RP, Edwards RH, Rodriguez I, and Carleton A.
Nat. Comm. 5: 3791.
Striatal Cholinergic Neurotransmission Requires VGLUT3.
Nelson AB, Bussert TG, Kreitzer AC, Seal RP.
J Neurosci. 34(26):8772-7.
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Striatal cholinergic interneurons drive GABA release from dopamine terminals.
Nelson AB, Hammack N, Yang CF, Shah NM, Seal RP, Kreitzer AC.
Neuron.82(1):63-70.
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2013
TAFA4, a Chemokine-Like Protein, Modulates Injury-Induced Mechanical and Chemical Pain Hypersensitivity in Mice.
Delfini MC, Mantilleri A, Gaillard S, Hao J, Reynders A, Malapert P, Alonso S, Francois A, Barrere C, Seal R, Landry M, Eschallier A, Alloui A, Bourinet E, Delmas P, Le Feuvre Y, Moqrich A.
Cell Rep. 5(2): 378-388.
Transcript Expression of Vesicular Glutamate Transporters in Lumbar Dorsal Root Ganglia and the Spinal Cord of Mice-Effects of Peripheral Axotomy or Hindpaw Inflamation.
Malet M, Vieytes CA, Lundgren KH, Seal RP, Tomasella E, Seroogy KB, Hökfelt T, Gebhart GF, Brumovsky PR.
Neuroscience. 248C: 95-111.
Expression of Vesicular Glutamate Transporters in Sensory and Autonomic Neurons Innervating the Mouse Bladder.
Brumovsky PR, Seal RP, Lundgren KH, Seroogy KB, Watanabe M, Gebhart GF.
J Urol. 89(6): 2342-2349.
2012
Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.
Akil O, Seal RP, Burke K, Wang C, Alem A, During MJ, Edwards RH, Lustig LR.
Neuron. 75(2):283-93.
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NA(v)1.8 expression is not restricted to noiceptors in mouse peripheral nervous system.
Shields SD, Ahn HS, Yang Y, Han C, Seal RP, Wood JN, Waxman SG and Dib-Hajj SD.
Pain 153 (10): 2017-2030.
2011
Genetic Targeting and Physiological Features of VGLUT3+ Amacrine Cells.Grimes, WN*, Seal, RP*, Oesch, NW*, Edwards, RH and Diamond, JS.
Vis. Neurosci. 5:381-392.
Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum.Brumovsky PR, Robinson DR, La JH, Lundgren KH, Albers KM, Kiyatkin ME, Seal RP, Edwards RH, Watanabe M, Hökfelt T, Gebhart GF.
J Comp Neurol. Epub DOI: 10.1002/cne.22730
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Cholinergic Interneurons Mediate Fast VGluT3-dependent Glutamatergic Transmission in the Striatum.Higley MJ*, Gittis A*, Oldenberg, IA*, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, and Sabatini BL.
PLoS One 6(4): e19155.
2010
Glutamate release at GABA/glycinergic Synapses is Critical for the Refinement of an Inhibitory Map.Noh J, Seal RP, Garver, JA, Edwards RH, and Kandler K.
Nature Neurosci. 13(2): 232-238. PMCID: PMC2832847.
2009
Injury–Induced Mechanical Hypersensitivity requires C-Low Threshold Mechanoreceptors.
Seal RP*, Wang X*, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, and Edwards, RH.
Nature 462: 651-655. PMCID: PMC2810205. *See News and Views by Drew and MacDermott. Nature 462: 580-581.
Synaptic and Extrasynaptic Factors Governing Glutamatergic Retinal Waves.Blankenship AG, Ford KJ, Johnson, J, Seal RP, Edwards RH, Copenhagen DR, and Feller MB.
Neuron 62 (2): 230-241. PMCID: PMC2807181.
2008
Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.
Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH.
Neuron. 2008 Jan 24;57(2):263-75.
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Can One Neuron Release More than One Neurotransmitter? Ask the Brains. Seal RP.
Scientific American Mind August Issue
2006
The Diverse Roles of Vesicular Glutamate Transporter 3. Seal RP and Edwards RH.
Handb. Exp. Pharmacol.175: 137-150. Review
Functional Implications of Neurotransmitter Co-release: Glutamate and GABA Share the Load. Seal RP and Edwards RH.
Curr. Opin. Pharmacol. 6 (1): 114-119. Review